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A welcoming home for HD research

Helping people make sense of Huntington's disease.

An open AI research home for people touched by Huntington's disease. Chat with the actual papers, in plain language, in any of 22 languages.

Start by telling us who you are arrow_downward

We are data scientists, not doctors. This is a research and education tool. For care decisions, please reach out to HDSA, HDBuzz, HDYO, or your own neurologist.

Who are you?

Tell us once. The hub adapts.

Pick the lens that matches you. The chat, the explainers, and the suggestions on this page change to fit.

Autonomous research agents
Refreshed today at 11:54 UTC · 20 papers · 30 trials · 20 targets
draft preprint_scout
Preprint scout indexed 13 HD preprints from biorxiv + medrxiv
today at 11:54 UTC
science experiment_runner
Experiment #005 published
today at 11:48 UTC
science experiment_runner
Experiment #001 published
today at 11:48 UTC
science experiment_runner
Experiment #003 published
today at 11:48 UTC
cloud_sync data_fetcher
Daily data refresh landed on main
yesterday
biotech hypothesis_refiner
Hypothesis refiner reviewed 5 drug ideas
May 5
menu_book paper_scout
Paper scout ingested 76 papers
May 5
What the agents pulled this week
Daily refresh · runningEdge pipeline · runs weeklyExperiments shipped · 5Active hypotheses · 5
What we've learned

Five experiments. Honest writeups. Reproducible.

Each one asks one question, runs Gemma 4 or its predecessors over real PubMed papers, and ships the result, including what didn't work.

EXP-001 Mar 27, 2026

First-look LLM triage: 22 HD abstracts on Llama 3.1

Post-translational modifications of huntingtin (phosphorylation, SUMOylation, O-GlcNAcylation) are getting significant research attention as potential drug targets.

Model: llama3.1:8b Read the writeup arrow_forward
EXP-002 Mar 30, 2026

Full-text deep read: 16 HD papers on Llama 3.1

The K845N variant of LIG1 confers enhanced substrate discrimination and increased repair fidelity, suppressing somatic CAG expansion in mice.

Model: llama3.1:8b Read the writeup arrow_forward
EXP-003 Apr 02, 2026

Model comparison: qwen3.5 vs Llama 3.1 on the EXP-002 corpus

A model-comparison run: re-analyzed the Experiment #2 corpus with qwen3.5:27b. Writeup available with the raw results and reproducibility notes.

Model: qwen3.5:27b Read the writeup arrow_forward
EXP-003-GEMMA Apr 02, 2026

Gemma 4 finds what Llama missed: multi-mechanism HD pathology

Neurodegeneration is not attributable to a single mechanism but results from a complex, interacting pathogenic network involving protein misfolding/aggregation, mitochondrial dysfunction, neuroinflammation, metabolic dysregulation, and gut dysbiosis, necess...

Model: gemma4:latest Read on GitHub open_in_new
EXP-004 Apr 07, 2026

Somatic CAG expansion drug screen (75-paper sweep)

Screened 75 papers across MSH3, FAN1, PMS1, MLH1, LIG1, the MutSbeta to MutLgamma to LIG1 pathway now driving HD drug development at LoQus23, Harness, Skyhawk, and Rgenta.

Model: gemma4:latest Read the writeup arrow_forward
EXP-005 Apr 19, 2026

Expanded corpus: the two-track HD pathology model

"Two-Track" Pathology Model: HD is increasingly seen as a confluence of two distinct processes: Track 1 (primary genetic/structural damage to HTT) and Track 2 (secondary metabolic and immune failure).

Model: gemma4:latest Read on GitHub open_in_new
How the Hub works

Pick a topic. Read what it means. Then do something with it.

Huntingtin-lowering (ASOs and gene therapy)

A strategy worth watching A simple idea, big stakes

Picture the huntingtin protein as a faulty thermostat that someone left turned up too high. Huntingtin-lowering programs try to turn the dial back down, so the brain has less of the harmful version to deal with in the first place.

What it is

A family of treatments that tries to make the brain produce less of the huntingtin protein. Some are repeat injections, some are a one-time gene therapy.

Read this at:
Do something with it
What the Hub is tracking today
20
Recent Papers
30
Active Trials
24
Recruiting Now
16+
Known Targets

Updated May 25, 2026 at 11:54 AM. Auto-refreshed daily from PubMed, ClinicalTrials.gov, HDBuzz, and Open Targets.

What's Happening Now

HD News + Breakthroughs

More on HDBuzz open_in_new
Thu, 21 May 2026

Tagging the Trash: Turnover of Toxic Huntingtin 
Mon, 18 May 2026

Prilenia’s Application for European Approval of Pridopidine Withdrawn
Thu, 14 May 2026

Intruders in the Brain: What a Pig Model Reveals about Immune Cells in HD
Mon, 11 May 2026

The Great Care Conundrum: What “Good” Care Looks Like in Huntington’s Disease
Thu, 07 May 2026

A Second Path: uniQure Plans Regulatory Filing for AMT-130 in the UK
Fresh from PubMed

Latest Research Papers

All HD papers open_in_new
2026 May — CNS & neurological disorders drug target
protein structure

Understanding Huntington's Disease: Epidemiology, Mechanisms, and Modeling Approaches.

Huntington's disease (HD) is a monogenic, autosomal dominant neurodegenerative disorder. Huntington's disease is caused by a CAG trinucleotide repeat expansion in exon 1 of the huntingtin gene, which

PubMed open_in_new
2026 May — JCI insight
biomarkerneuroinflammationprotein structure

Metabolic reprogramming is critical to microglial activation in Huntington's disease.

Huntington's disease (HD) is a fatal neurodegenerative disease caused by an expanded polyglutamine (CAG) repeat in the N-terminal of the huntingtin protein (HTT). Microglial activation and elevated pr

PubMed open_in_new
2026 Jun — Disease models & mechanisms
protein structure

Induced pluripotent stem cells from a transgenic minipig model of Huntington's disease reveal early

Huntington's disease (HD) is a neurodegenerative autosomal dominant hereditary disease caused by a CAG triplet repeat expansion mutation in the gene encoding the huntingtin (HTT) protein. The main fea

PubMed open_in_new
2026 May — Molecular and cellular biochemistry
protein structure

Inhibition of the mitochondrial pyruvate carrier attenuates the integrated stress response activatio

Mitochondrial pyruvate carrier (MPC) inhibition was found protective in models of neurodegenerative diseases, such as Alzheimer's and Parkinson's. However, little is known about MPC as a potential the

PubMed open_in_new
2026 May — Biochemical and biophysical research com
protein structure

Early dysregulation of sphingomyelin metabolism in the striatum of Huntington's disease mouse models

Huntington's disease (HD) is a devastating neurodegenerative disorder caused by mutant huntingtin protein, leading to progressive motor, cognitive, and behavioral decline. This study investigates the

PubMed open_in_new
2026 May — Laeknabladid
autophagyprotein structure

[Huntington´s disease - overview].

Huntington's disease (HD) is a rare, autosomal dominant neurodegenerative disorder characterized by progressive movement disturbances, psychiatric symptoms, and cognitive impairment. The disease is ca

PubMed open_in_new
Reasons for Optimism

Active Clinical Trials

30 trials, 72,274 patients enrolled, 24 recruiting now

ClinicalTrials.gov open_in_new
NCT ID Title Sponsor Phase Status Intervention
NCT07010705 Digital Measures for Clinical Trial Endpoints in H University of Rochester N/A Recruiting ActiGraph LEAP; Axivity AX6
NCT00874783 Development of IPS from Donated Somatic Cells of P Hadassah Medical Organiza N/A Recruiting
NCT06828471 Social Cognition Training in Individuals With Hunt Rush University Medical C NA Recruiting Social Cognition Training
NCT06254482 An Extension Study to Evaluate the Long-Term Safet Novartis Pharmaceuticals PHASE2 Active Not Recruiting Votoplam
NCT07513844 Optimizing Parameters of Low-Intensity Focused Ult First Affiliated Hospital NA Recruiting Low-Intensity Focused Ultrasound Stimula
NCT06448546 Gut Microbiomes in HD University of Central Flo N/A Recruiting
NCT06209515 Sociodemographic Factors and Criminal Behaviour Pr Kuopio University Hospita N/A Active Not Recruiting
NCT06667414 Frequency of Selected Single Nucleotide Polymorphi Hoffmann-La Roche N/A Recruiting
NCT06807892 Comparison of Two Cognitive-Motor Rehabilitation A University Hospital, Ange NA Recruiting Synergistic management; Sequential manag
NCT07136844 Gait Analysis Parameter and Upper Limb Evaluation Centre Hospitalier Univer NA Recruiting Syde; Dynamometric measurements of muscl
Open Research

Published Research Ideas

AI-assisted repurposing ideas with explicit uncertainty. These are starting points for review, not recommendations or validated findings.

Read Experiment #1: Full Analysis arrow_forward
Tocilizumab Exploring
Target: IL-6 / neuroinflammation

IL-6 receptor blockade may reduce inflammation from mutant huntingtin aggregation

Latest score: 80/100 Support: 0 Concerns: 0 Updated: 2026-03-29
Metformin Exploring
Target: mTOR / AMPK / autophagy

Promotes autophagy which may help clear mutant HTT aggregates

Latest score: 72/100 Support: 0 Concerns: 0 Updated: 2026-03-29
Rapamycin Exploring
Target: mTOR

mTOR inhibitor demonstrated clearance of mutant HTT in preclinical models

Latest score: 68/100 Support: 0 Concerns: 0 Updated: 2026-03-29
Riluzole Known/Tested
Target: Glutamate excitotoxicity

Glutamate release inhibitor, may reduce excitotoxicity in HD

Latest score: 60/100 Support: 0 Concerns: 1 Updated: 2026-03-29
Lithium Exploring
Target: TDP-43 / GSK-3β

May reduce TDP-43 phosphorylation and aggregation via GSK-3β inhibition, relevant to newly discovered HD-TDP-43 connection

Latest score: 55/100 Support: 0 Concerns: 0 Updated: 2026-03-29

Important: These hypotheses are triage artifacts, not evidence of efficacy. They have not been clinically validated, experimentally confirmed, or expert-reviewed unless explicitly stated.

These cards are generated from data/hypotheses_tracker.json, not hand-picked homepage copy. Are you an HD researcher? We'd love your feedback. Review and discuss on GitHub

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Who This Is For

This is best viewed as open research infrastructure: a place where data scientists, AI engineers, bioinformaticians, and researchers can test whether agent workflows actually help with literature review, hypothesis triage, and research communication.

Data Scientists + AI/ML Engineers

Run our autonomous research agents. Fork the repo. Try different models. Add experiments. This is open-source infrastructure you can build on.

Researchers + Domain Experts

Review our AI-generated hypotheses. Spot what's promising and what's wrong. Your expertise is what turns computational ideas into real science. Join the discussion.

Students + Curious Builders

Want to learn how AI applies to drug discovery? Read our experiment reports — we show every step, what worked, and what didn't. No PhD required to follow along.

For patients and families: This is not a medical resource. For support, guidance, and verified medical information, please go to HDSA, HDBuzz, or HDYO. They have doctors and scientists reviewing every word. We don't.

Trusted Organizations

Resources for Patients, Families + Researchers

These organizations are the real experts. We link to them because they do essential work.

HDSA
Support + Advocacy

Huntington's Disease Society of America. Find local support groups, social workers, Centers of Excellence. The primary advocacy organization in the US.
HDBuzz
Research News in Plain Language

Scientists explain HD research in words everyone can understand. The best place to follow new developments without needing a PhD.
HDYO
Young People

Huntington's Disease Youth Organization. Resources specifically for young people affected by HD — teens, young adults, and young families.
Enroll-HD
Join Research

The world's largest observational study for HD families. Your data helps researchers understand HD and design better clinical trials.
European HD Network
International Research

EHDN coordinates HD research across Europe. Clinical trials, registries, and working groups advancing the science globally.
HD Reach
Rehab + Exercise

Evidence-based rehabilitation exercises designed for people with HD. Physical therapy, speech therapy, and occupational therapy resources.
Make a Difference

Ways to Get Involved

Whether you're a patient, family member, researcher, developer, or just someone who cares.

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Join a Clinical Trial

24 HD trials are actively recruiting right now. Your participation directly accelerates the path to treatment.

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Contribute to Open Source

Our research agent, literature scanner, and drug repurposing tools are all open source. Data scientists, ML engineers, and bioinformaticians welcome.

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Share Your Story

Patient and family stories drive awareness and funding. Share your experience with HDSA or on social media to help others feel less alone.

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Donate

Research funding saves lives. HDSA and CHDI Foundation fund the science that makes breakthroughs like AMT-130 possible.

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Share Feedback or Ideas

Are you an HD researcher? See something interesting in our hypotheses? Spot an error? We want to hear from you — every correction makes this better.

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